Studies show that adding fats to cannabis consumption can improve the absorption and bioavailability of cannabinoids in the body. This mainly involves saturated fats from animal sources, although saturated fats from plant sources like coconut oil and cocoa butter can also enhance cannabis absorption.
On the other hand, studies also show that a diet rich in saturated fat raises the threshold in the reward system. The reward system includes various neurotransmitters such as dopamine, serotonin, various endorphins, acetylcholine, etc. It has been found that saturated fat reduces the signaling of dopamine D1 receptors in the nucleus accumbens, indicating suppression of dopaminergic signaling. The result is that while saturated fats help enhance the high, excessive use eventually leads to increased consumption of these substances in anticipation of appropriate rewards, i.e., the desire to achieve the same psychoactive effect.
Since I am going to talk mainly about fat consumption along with psychoactive substances, I will expand a bit on the research itself before moving on to religious studies: Cannabinoids are lipophilic, meaning they tend to dissolve and become more bioavailable in the presence of fats. Saturated fats have long-chain fatty acids. These fatty acids enhance the absorption and transport of cannabinoids through the intestinal lymphatic system, increasing the systemic exposure of cannabinoids. This has been proven in rat experiments, where absorption was significantly higher (250%-300%) in the presence of fats. The intestinal lymphatic system plays a critical role in the absorption of cannabis when combined with fats. Fats help stimulate the lymphatic system to distribute and transport cannabinoids throughout the body. Consuming fats before or during cannabis intake causes the liver and gallbladder to release bile, which helps emulsify (a mixture between two liquids that do not mix, like oil or milk and water) the fats and cannabinoids in the digestive system, making them more available for absorption.
And now to the main course: The connection between fats and cannabinoids specifically supports the theory that cannabis was the original psychedelic sacrament. However, this is not necessary because we see that animal fat in general plays a role in the reward system, and our ancestors knew this, probably through trial and error. This is why many of the potions described in legends (and scriptures) are said to have been consumed with milk. This is why we find in the Bible descriptions of oil libation along with incense burning, to enhance the absorption of the incense by those present in the “hot box”. This is why in many creation myths, sacrifice plays a role, especially the sacrifice of a bull. This is also why in many eschatological myths, it involves a correction of the first sacrifice (or an analogy to it), and a bull will be sacrificed.
In Jewish mythology, it is said that the first human sacrifice was a bull, and in the future, at the final meal, the wild ox will be sacrificed. In Zoroastrianism (in the Bundahishn), it is said that in the end times, the savior (Sōšyāns) will slaughter a bull named Hadayanš and use its fat to prepare the “Haoma”. It is also said that at the creation of the world, as part of the immortal entities accompanying Ahura Mazda, entities were created to guard the earth, the plant that grows on it, the bull from which fat is derived, and of course, the fire. At the creation of the world, along with the first man Gayomard, a bull named Gawōdād (Gavaevodata in Avestan. In Persian, it is gaw i ew-dad, or gawodad. Gav, like cow in English), and a plant named Amurdād (immortality, in Indo-Iranian terminology “psychedelia”) were created, but Ahriman killed the man and the bull and corrupted the plant. It is said that Zoroaster changed the formula of the Haoma sacrifice by removing its psychoactive component. Some say he was against using the plant itself and provided a less psychoactive alternative, while others say he simply wanted to moderate the heavy effect by refusing to allow the use of animal fat, which caused the ritual to get out of control and turn into an orgy.
Regarding Zoroaster, according to the legend, he descended to the world in several parts: the aura, the soul, and the essence of the body. The aura descended in fire, the soul descended in the Haoma plant, and the essence of the body descended through water or alternatively, milk. In fact, the rainwater that falls from the sky waters the earth, the earth grows herbs, the cows eat them and produce milk, and the milk is used for libation. Zoroaster’s mother was called “Dugdav”, “the one with milking cows”.
Fertility goddesses are described as having “cow eyes” (βοῶπις), probably because of the glazed look of someone who drank the potion (kykeon also made of honey). Apis himself was the son of the fertility goddess Hathor and was considered a mediator between man and god, and responsible for birth and rebirth, two images of the psychedelic experience. The cow was a symbol of fertility, but mainly a symbol of altered consciousness, due to its milk and apparently its fat. Now it makes sense why.